References
Query Results -- Details
MGI Accession ID: MGI:2149247
J Number: J:71158
Other Accession IDs:
Title: Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism.
Authors: Fujigaki S; Saito K; Sekikawa K; Tone S; Takikawa O; Fujii H; Wada H; Noma A; Seishima M
Journal: Eur J Immunol
Volume: 31
Issue: 8
Date: 2001 Aug
Year: 2001
Pages: 2313-8
Review Status: Peer Reviewed
Abstract:
Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the L-tryptophan-kynurenine pathway, which converts an essential amino acid, L-tryptophan, to N-formylkynurenine. It has been speculated that IFN-gamma is a dominant IDO inducer in vivo. The present study used IFN-gamma or TNF-alpha gene-disrupted mice and IFN-gamma antibody-treated mice to demonstrate that lipopolysaccharide (LPS)-induced systemic IDO is largely dependent on TNF-alpha rather than IFN-gamma. IFN-gamma-independent IDO induction was also demonstrated in vitro with LPS-stimulated monocytic THP-1 cells. These findings clearly indicate that there is an IFN-gamma-independent mechanism of IDO induction in addition to the IFN-gamma-dependent mechanism.
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