References
Query Results -- Details
MGI Accession ID: MGI:2137829
J Number: J:70602
Other Accession IDs:
Title: Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor.
Authors: Kitamura T; Kido Y; Nef S; Merenmies J; Parada LF; Accili D
Journal: Mol Cell Biol
Volume: 21
Issue: 16
Date: 2001 Aug
Year: 2001
Pages: 5624-30
Review Status: Peer Reviewed
Abstract:
Receptors of the insulin/insulinlike growth factor (IGF) family have been implicated in the regulation of pancreatic beta-cell growth and insulin secretion. The insulin receptor-related receptor (IRR) is an orphan receptor of the insulin receptor gene (Ir) subfamily. It is expressed at considerably higher levels in beta cells than either insulin or IGF-1 receptors, and it has been shown to engage in heterodimer formation with insulin or IGF-1 receptors. To address whether IRR plays a physiologic role in beta-cell development and regulation of insulin secretion, we have characterized mice lacking IRR and generated a combined knockout of Ir and Irr. We report that islet morphology, beta-cell mass, and secretory function are not affected in IRR-deficient mice. Moreover, lack of IRR does not impair compensatory beta-cell hyperplasia in insulin-resistant Ir(+/-) mice, nor does it affect beta-cell development and function in Ir(-/-) mice. We conclude that glucose-stimulated insulin secretion and embryonic beta-cell development occur normally in mice lacking Irr.
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