References
Query Results -- Details
MGI Accession ID: MGI:55613
J Number: J:7142
Other Accession IDs:
Title: Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.
Authors: Schnieke A; Harbers K; Jaenisch R
Journal: Nature
Volume: 304
Issue: 5924
Date: 1983 Jul 28-Aug 3
Year: 1983
Pages: 315-20
Review Status: Peer Reviewed
Abstract:
Experimental insertion of a retrovirus into the germ line of mice has resulted in an embryonic recessive lethal mutation. Integration of the proviral genome occurred at the 5' end of the alpha 1(I) collagen gene, leading to complete transcriptional block. Developmental arrest of embryos homozygous at the mutated allele coincides with high expression of the gene in normal embryogenesis. Insertion mutagenesis by retroviruses may offer a general approach to the identification and isolation of genes which are transcriptionally active during mammalian development.
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