References
Query Results -- Details
MGI Accession ID: MGI:2135373
J Number: J:69731
Other Accession IDs:
Title: Activation of the met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice.
Authors: Wang R; Ferrell LD; Faouzi S; Maher JJ; Bishop JM
Journal: J Cell Biol
Volume: 153
Issue: 5
Date: 2001 May 28
Year: 2001
Pages: 1023-34
Review Status: Peer Reviewed
Abstract:
Overexpression is the most common abnormality of receptor tyrosine kinases (RTKs) in human tumors. It is presumed that overexpression leads to constitutive activation of RTKs, but the mechanism of that activation has been uncertain. Here we show that overexpression of the Met RTK allows activation of the receptor by cell attachment and that this form of activation can be tumorigenic. Transgenic mice that overexpressed Met in hepatocytes developed hepatocellular carcinoma (HCC), one of the human tumors in which Met has been implicated previously. The tumorigenic Met was activated by cell attachment rather than by ligand. Inactivation of the transgene led to regression of even highly advanced tumors, apparently mediated by apoptosis and cessation of cellular proliferation. These results reveal a previously unappreciated mechanism by which the tumorigenic action of RTKs can be mediated, provide evidence that Met may play a role in both the genesis and maintenance of HCC, and suggest that Met may be a beneficial therapeutic target in tumors that overexpress the receptor.
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