References
Query Results -- Details
MGI Accession ID: MGI:1932807
J Number: J:68525
Other Accession IDs:
Title: FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.
Authors: Clark JC; Tichelaar JW; Wert SE; Itoh N; Perl AK; Stahlman MT; Whitsett JA
Journal: Am J Physiol Lung Cell Mol Physiol
Volume: 280
Issue: 4
Date: 2001 Apr
Year: 2001
Pages: L705-15
Review Status: Peer Reviewed
Abstract:
Transgenic mice in which fibroblast growth factor (FGF)-10 was expressed in the lungs of fetal and postnatal mice were generated with a doxycycline-inducible system controlled by surfactant protein (SP) C or Clara cell secretory protein (CCSP) promoter elements. Expression of FGF-10 mRNA in the fetal lung caused adenomatous malformations, perturbed branching morphogenesis, and caused respiratory failure at birth. When expressed after birth, FGF-10 caused multifocal pulmonary tumors. FGF-10-induced tumors were highly differentiated papillary and lepidic pulmonary adenomas. Epithelial cells lining the tumors stained intensely for thyroid transcription factor (TTF)-1 and SP-C but not CCSP, indicating that FGF-10 enhanced differentiation of cells to a peripheral alveolar type II cell phenotype. Withdrawal from doxycycline caused rapid regression of the tumors associated with rapid loss of the differentiation markers TTF-1, SP-B, and proSP-C. FGF-10 disrupted lung morphogenesis and induced multifocal pulmonary tumors in vivo and caused reversible type II cell differentiation of the respiratory epithelium.
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