References
Query Results -- Details
MGI Accession ID: MGI:55428
J Number: J:6957
Other Accession IDs:
Title: TOr1 is a novel, variant form of mouse chromosome 17 with a deletion in a partial t haplotype.
Authors: Silver LM; Lukralle D; Garrels JI
Journal: Nature
Volume: 301
Issue: 5899
Date: 1983 Feb 3
Year: 1983
Pages: 422-4
Review Status: Peer Reviewed
Abstract:
Moutier discovered, in a mouse from a noninbred Swiss/Orleans laboratory stock, a spontaneous dominant mutation which mapped to the T locus, and which was named TOr1. Genetic analyses indicated that TOr1 was not a simple mutation at one locus, but rather a deletion over a 3-centimorgan region of chromosome 17 that included both T and quaking (qk). Further experiments reported by Erickson et al., and a more comprehensive study by Hammerberg, have demonstrated that TOr1 is associated with recessive genetic properties affecting sperm function, characteristic of the proximal region of complete t haplotypes. These results were interpreted as evidence for the location of proximal t haplotype 'sperm factors' within the region deleted by TOr1. We now provide conclusive biochemical and genetic evidence that the 'TOr1 haplotype' is inseparably associated with a chromosomal region derived from a naturally occurring mouse t haplotype. Hence, it is likely that the t haplotype properties of TOr1 are a consequence not of the deletion itself, but of closely linked mutant t haplotype genes.
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