References
Query Results -- Details
MGI Accession ID: MGI:1929918
J Number: J:67125
Other Accession IDs:
Title: Impaired prostate tumorigenesis in Egr1-deficient mice.
Authors: Abdulkadir SA; Qu Z; Garabedian E; Song SK; Peters TJ; Svaren J; Carbone JM; Naughton CK; Catalona WJ; Ackerman JJ; Gordon JI; Humphrey PA; Milbrandt J
Journal: Nat Med
Volume: 7
Issue: 1
Date: 2001 Jan
Year: 2001
Pages: 101-7
Review Status: Peer Reviewed
Abstract:
The transcription factor early growth response protein 1 (EGR1) is overexpressed in a majority of human prostate cancers and is implicated in the regulation of several genes important for prostate tumor progression. Here we have assessed the effect of Egr1 deficiency on tumor development in two transgenic mouse models of prostate cancer (CR2-T-Ag and TRAMP). Using a combination of high-resolution magnetic resonance imaging and histopathological and survival analyses, we show that tumor progression was significantly impaired in Egr1-/- mice. Tumor initiation and tumor growth rate were not affected by the lack of Egr1; however, Egr1 deficiency significantly delayed the progression from prostatic intra-epithelial neoplasia to invasive carcinoma. These results indicate a unique role for Egr1 in regulating the transition from localized, carcinoma in situ to invasive carcinoma.
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