References
Query Results -- Details
MGI Accession ID: MGI:55281
J Number: J:6809
Other Accession IDs:
Title: The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains.
Authors: Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3d
Journal: Genetics
Volume: 100
Issue: 1
Date: 1982 Jan
Year: 1982
Pages: 79-87
Review Status: Peer Reviewed
Abstract:
Forty-four inbred and four randombred rat strains and 20 inbred mouse strains were examined for their Ah phenotype by determining the induction of liver microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity (EC 1.14.14.1) by intraperitoneal treatment with either beta-naphthoflavone or 3-methylcholanthrene. All 48 rat strains were found to be Ah-responsive. The maximally induced hydroxylase specific activities of the ALB/Pit, MNR/Pit, MR/Pit, SHR/Pit, and Sprague-Dawley strains were of the same order of magnitude as the basal hydroxylase specific activities of the ACI/Pit, F344/Pit, OKA/Pit, and MNR/N strains. Six of the 20 mouse strains were Ah-nonresponsive (i.e. lacking the normal induction response and presumably lacking detectable amounts of the Ah receptor). The basal hydroxylase specific activities of the BDL/N, NFS/N, STAR/N, and ST/JN mouse strains were more than twice as high as the maximally induced hydroxylase specific activity of the CBA/HT strain.--To date, 24 Ah-nonresponsive mouse strains have been identified, out of a total of 68 known to have been characterized. The reasons for not finding a single Ah-nonresponsive inbred rat strain--as compared with about one Ah-nonresponsive inbred mouse strain found for every three examined--remain unknown.
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