References
Query Results -- Details
MGI Accession ID: MGI:1929257
J Number: J:66802
Other Accession IDs:
Title: Multiple defects of immune cell function in mice with disrupted interferon-gamma genes [see comments]
Authors: Dalton DK; Pitts-Meek S; Keshav S; Figari IS; Bradley A; Stewart TA
Journal: Science
Volume: 259
Issue: 5102
Date: 1993 Mar 19
Year: 1993
Pages: 1739-42
Review Status: Peer Reviewed
Abstract:
Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally and were healthy in the absence of pathogens. However, mice deficient in IFN-gamma had impaired production of macrophage antimicrobial products and reduced expression of macrophage major histocompatibility complex class II antigens. IFN-gamma-deficient mice were killed by a sublethal dose of the intracellular pathogen Mycobacterium bovis. Splenocytes exhibited uncontrolled proliferation in response to mitogen and alloantigen. After a mixed lymphocyte reaction, T cell cytolytic activity was enhanced against allogeneic target cells. Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system.
Additional Information:
