References
Query Results -- Details
MGI Accession ID: MGI:1891783
J Number: J:65106
Other Accession IDs:
Title: Cytokine dysregulation induced by apoptotic cells is a shared characteristic of murine lupus
Authors: Koh JS; Wang Z; Levine JS
Journal: J Immunol
Volume: 165
Issue: 8
Date: 2000 Oct 15
Year: 2000
Pages: 4190-201
Review Status: Peer Reviewed
Abstract:
Of the multiple murine models of autoimmunity, the three most closely resembling human systemic lupus erythematosus (SLE) are the MRL/lpr, New Zealand Black/White F(1), and male BXSB. Although these strains share many disease characteristics, no common cellular defect has previously been found in prediseased mice from all these strains. We show in this study that macrophages from prediseased mice of all three SLE-prone strains, as well as macrophages from mice whose genomes contribute to the development of SLE (MRL/+, New Zealand White, New Zealand Black, female BXSB, and LG/J), have an identical and profound defect in cytokine expression that is triggered by apoptotic cells. Strikingly, none of 13 nonautoimmune strains tested exhibited this defect. Given that apoptotic Ags have been increasingly recognized as the target of autoantibodies, a defect in cytokine expression that is triggered by apoptotic cells has broad potential to upset the balance between tolerance and immunity.
