References
Query Results -- Details
MGI Accession ID: MGI:1891540
J Number: J:64978
Other Accession IDs:
Title: The underwhite (uw) locus acts autonomously and reduces the production of melanin
Authors: Lehman AL; Silvers WK; Puri N; Wakamatsu K; Ito S; Brilliant MH
Journal: J Invest Dermatol
Volume: 115
Issue: 4
Date: 2000 Oct
Year: 2000
Pages: 601-6
Review Status: Peer Reviewed
Abstract:
The mouse has provided several significant models for hypopigmentation disorders, including the major forms of albinism. Mutations at the mouse underwhite locus confer one of the most severe hypopigmentation phenotypes, similar to mutations at the pink-eyed dilution locus that is a model for type 2 oculocutaneous albinism. A melanocyte cell line established from underwhite mutant mice failed to pigment under conditions that support pigment production in wild-type melanocytes and melanoblasts from underwhite skin graft transplants failed to produce melanin in normal skin, demonstrating that the action of the gene encoded by the underwhite locus is intrinsic to melanocytes. Mice with mutations at the underwhite locus and either the pink-eyed dilution locus or the melanocortin receptor 1 locus exhibited more severe hypopigmentation than either mutation alone, suggesting that the actions of these genes are independent. These results demonstrate that the underwhite locus is a major determinant of mammalian pigmentation. Key words: melanocyte/mouse mutations/pigmentation.
Additional Information:
