References
Query Results -- Details
MGI Accession ID: MGI:1860404
J Number: J:63080
Other Accession IDs:
Title: Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation.
Authors: Li B; Yu H; Zheng W; Voll R; Na S; Roberts AW; Williams DA; Davis RJ; Ghosh S; Flavell RA
Journal: Science
Volume: 288
Issue: 5474
Date: 2000 Jun 23
Year: 2000
Pages: 2219-22
Review Status: Peer Reviewed
Abstract:
T helper 1 (TH1) cells mediate cellular immunity, whereas TH2 cells potentiate antiparasite and humoral immunity. We used a complementary DNA subtraction method, representational display analysis, to show that the small guanosine triphosphatase Rac2 is expressed selectively in murine TH1 cells. Rac induces the interferon-gamma (IFN-gamma) promoter through cooperative activation of the nuclear factor kappa B and p38 mitogen-activated protein kinase pathways. Tetracycline-regulated transgenic mice expressing constitutively active Rac2 in T cells exhibited enhanced IFN-gamma production. Dominant-negative Rac inhibited IFN-gamma production in murine T cells. Moreover, T cells from Rac2-/- mice showed decreased IFN-gamma production under TH1 conditions in vitro. Thus, Rac2 activates TH1-specific signaling and IFN-gamma gene expression.
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