References
Query Results -- Details
MGI Accession ID: MGI:1859072
J Number: J:62544
Other Accession IDs:
Title: Decreased expression of striatal signaling genes in a mouse model of Huntington's disease.
Authors: Luthi-Carter R; Strand A; Peters NL; Solano SM; Hollingsworth ZR; Menon AS; Frey AS; Spektor BS; Penney EB; Schilling G; Ross CA; Borchelt DR; Tapscott SJ; Young AB; Cha JH; Olson JM
Journal: Hum Mol Genet
Volume: 9
Issue: 9
Date: 2000 May 22
Year: 2000
Pages: 1259-71
Review Status: Peer Reviewed
Abstract:
To understand gene expression changes mediated by a polyglutamine repeat expansion in the human huntingtin protein, we used oligonucleotide DNA arrays to profile approximately 6000 striatal mRNAs in the R6/2 mouse, a transgenic Huntington's disease (HD) model. We found diminished levels of mRNAs encoding components of the neurotransmitter, calcium and retinoid signaling pathways at both early and late symptomatic time points (6 and 12 weeks of age). We observed similar changes in gene expression in another HD mouse model (N171-82Q). These results demonstrate that mutant huntingtin directly or indirectly reduces the expression of a distinct set of genes involved in signaling pathways known to be critical to striatal neuron function.
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