References
Query Results -- Details
MGI Accession ID: MGI:54816
J Number: J:6340
Other Accession IDs:
Title: Somatomedin activity in sera of genetically small mice.
Authors: Nissley SP; Knazek RA; Wolff GL
Journal: Horm Metab Res
Volume: 12
Issue: 4
Date: 1980 Apr
Year: 1980
Pages: 158-64
Review Status: Peer Reviewed
Abstract:
Somatomedin activity as determined by the stimulation of [3H]thymidine incorporation into chick embryo fibroblast DNA, was measured in extracts of sera from genetically small mice. Somatomedin activity was low in the sera from growth hormone deficient mice [Snell (dw/dw), Ames (df/df), and little (lit/lit)] whereas somatomedin activity was normal in serum from the pygmy (pg/pg)) mouse, a mutant proposed as a model for growth hormone resistance. GH treatment of the Snell mouse resulted in an increase in somatomedin activity to normal levels.
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