References
Query Results -- Details
MGI Accession ID: MGI:1354852
J Number: J:61384
Other Accession IDs:
Title: Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling.
Authors: Brisken C; Heineman A; Chavarria T; Elenbaas B; Tan J; Dey SK; McMahon JA; McMahon AP; Weinberg RA
Journal: Genes Dev
Volume: 14
Issue: 6
Date: 2000 Mar 15
Year: 2000
Pages: 650-4
Review Status: Peer Reviewed
Abstract:
Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome this defect by ectopic expression of the protooncogene Wnt-1. Transplantation of mammary epithelia from Wnt-4(-)/(-) mice shows that Wnt-4 has an essential role in side-branching early in pregnancy. PR and Wnt-4 mRNAs colocalize to the luminal compartment of the ductal epithelium. Progesterone induces Wnt-4 in mammary epithelial cells and is required for increased Wnt-4 expression during pregnancy. Thus, Wnt signaling is essential in mediating progesterone function during mammary gland morphogenesis.
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