References
Query Results -- Details
MGI Accession ID: MGI:1353135
J Number: J:60292
Other Accession IDs:
Title: The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development.
Authors: Balomenos D; Martin-Caballero J; Garcia MI; Prieto I; Flores JM; Serrano M; Martinez-A C
Journal: Nat Med
Volume: 6
Issue: 2
Date: 2000 Feb
Year: 2000
Pages: 171-6
Review Status: Peer Reviewed
Abstract:
Here we show that the cell-cycle regulator p21 is involved in immune system function. T lymphocytes from p21-/- mice exhibit significant proliferative advantage over wild-type cells following prolonged stimulation, but not after primary activation. Consistent with this, p21-deficient mice accumulate abnormal amounts of CD4+ memory cells, and develop loss of tolerance towards nuclear antigens. Similar to human lupus, female p21-deficient mice develop antibodies against dsDNA, lymphadenopathy, and glomerulonephritis, leading to decreased viability. These data demonstrate a specialized role for p21 in the control of T-cell proliferation, tolerance to nuclear antigens, and female-prone lupus. These findings could be the basis for new therapeutic approaches to lupus.
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