References
Query Results -- Details
MGI Accession ID: MGI:54564
J Number: J:6087
Other Accession IDs:
Title: Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice.
Authors: Reske-Kunz AB; Scheid MP; Boyse EA
Journal: J Exp Med
Volume: 149
Issue: 1
Date: 1979 Jan 1
Year: 1979
Pages: 228-33
Review Status: Peer Reviewed
Abstract:
Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen. The salient feature of hr/hr mice, which are immunologically deficient, in comparison with +/hr segregants, was a gross disproportion in numbers of cells belonging to the Ly1 and Ly123 sets, at the age of 3--3.5 mo. At this age, Ly123 cells of hr/hr spleen outnumbered Ly1 cells by 2:1, whereas in +/hr spleens Ly123 cells were outnumbered by approximately 1:2. Cells from pooled lymph nodes of hr/hr mice did not show a correspondingly gross disporprotion of Ly1 and Ly123 cells. Total counts of splenic T cells, and of B cells, were not significantly different in hr/hr and +/hr mice.
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