References
Query Results -- Details
MGI Accession ID: MGI:1351265
J Number: J:59271
Other Accession IDs:
Title: T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.
Authors: Yamaguchi TP; Takada S; Yoshikawa Y; Wu N; McMahon AP
Journal: Genes Dev
Volume: 13
Issue: 24
Date: 1999 Dec 15
Year: 1999
Pages: 3185-90
Review Status: Peer Reviewed
Abstract:
Wnt3a encodes a signal that is expressed in the primitive streak of the gastrulating mouse embryo and is required for paraxial mesoderm development. In its absence cells adopt ectopic neural fates. Embryos lacking the T-box-containing transcription factors, Brachyury or Tbx6, also lack paraxial mesoderm. Here we show that Brachyury is specifically down-regulated in Wnt3a mutants in cells fated to form paraxial mesoderm. Transgenic analysis of the T promoter identifies T (Brachyury) as a direct transcriptional target of the Wnt signaling pathway. Our results suggest that Wnt3a, signaling via Brachyury, modulates a balance between mesodermal and neural cell fates during gastrulation.
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