References
Query Results -- Details
MGI Accession ID: MGI:1351097
J Number: J:59158
Other Accession IDs:
Title: Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability.
Authors: Eliceiri BP; Paul R; Schwartzberg PL; Hood JD; Leng J; Cheresh DA
Journal: Mol Cell
Volume: 4
Issue: 6
Date: 1999 Dec
Year: 1999
Pages: 915-24
Review Status: Peer Reviewed
Abstract:
Src kinase activity was found to protect endothelial cells from apoptosis during vascular endothelial growth factor (VEGF)-, but not basic fibroblast growth factor (bFGF)-, mediated angiogenesis in chick embryos and mice. In fact, retroviral targeting of kinase-deleted Src to tumor-associated blood vessels suppressed angiogenesis and the growth of a VEGF-producing tumor. Although mice lacking individual Src family kinases (SFKs) showed normal angiogenesis, mice deficient in pp60c-src or pp62c-yes showed no VEGF-induced vascular permeability (VP), yet fyn-/- mice displayed normal VP. In contrast, inflammation-mediated VP appeared normal in Src-deficient mice. Therefore, VEGF-, but not bFGF-, mediated angiogenesis requires SFK activity in general, whereas the VP activity of VEGF specifically depends on the SFKs, Src, or Yes.
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