References
Query Results -- Details
MGI Accession ID: MGI:1345916
J Number: J:57887
Other Accession IDs:
Title: A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.
Authors: Khasar SG; Lin YH; Martin A; Dadgar J; McMahon T; Wang D; Hundle B; Aley KO; Isenberg W; McCarter G; Green PG; Hodge CW; Levine JD; Messing RO
Journal: Neuron
Volume: 24
Issue: 1
Date: 1999 Sep
Year: 1999
Pages: 253-60
Review Status: Peer Reviewed
Abstract:
There is great interest in discovering new targets for pain therapy since current methods of analgesia are often only partially successful. Although protein kinase C (PKC) enhances nociceptor function, it is not known which PKC isozymes contribute. Here, we show that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid-associated hyperalgesia are markedly attenuated in PKCepsilon mutant mice, but baseline nociceptive thresholds are normal. Moreover, epinephrine-, carrageenan-, and nerve growth factor- (NGF-) induced hyperalgesia in normal rats, and epinephrine-induced enhancement of tetrodotoxin-resistant Na+ current (TTX-R I(Na)) in cultured rat dorsal root ganglion (DRG) neurons, are inhibited by a PKCepsilon-selective inhibitor peptide. Our findings indicate that PKCepsilon regulates nociceptor function and suggest that PKCepsilon inhibitors could prove useful in the treatment of pain.
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