References
Query Results -- Details
MGI Accession ID: MGI:54235
J Number: J:5758
Other Accession IDs:
Title: Effects of mutant steel alleles on leukemogenesis and life-span in the mouse.
Authors: Murphy ED
Journal: J Natl Cancer Inst
Volume: 58
Issue: 1
Date: 1977 Jan
Year: 1977
Pages: 107-10
Review Status: Peer Reviewed
Abstract:
Mutant alleles at the steel locus produce the pleiotropic effects of congenital anemia, sterility, and lack of hair pigmentation. Strain (WC/Re X C57BL/6)F1 Sl/Sld mice lived only half as long as heterozygotes and homozygous normal controls, differing only at the steel locus. Lymphocytic leukemia developed spontaneously in 37% of mice of the Sl/Sld genotype at an average age of 370 +/- 25 days and in 5% of heterozygotes and homozygous normal controls at 965 +/- 41 days. Severe ulcerative dermatitis occurred in 56% of Sl/Sld mice at an average age o4f 441 +/- 21 days and in 20% of heterozygotes and homozygous normal controls at 722 +/- 50 days. The mutant steel alleles provided an opportunity for study of the role of chronic anemia in life shortening and of a mechanism of gene action in spontaneous leukemogenesis.
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