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Query Results -- Details

MGI Accession ID: MGI:54203
J Number: J:5726
Other Accession IDs: Title: Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis.
Authors: Heiniger HJ; Huebner RJ; Meier H
Journal: J Natl Cancer Inst
Volume: 56
Issue: 5
Date: 1976 May
Year: 1976
Pages: 1073-4
Review Status: Peer Reviewed

Abstract:

Leukemia-prone hairless (HRS/J; hr/hr) mice had significantly higher leukemia virus titers than did the leukemia-resistant nonmutants (hr/ + and +/+). This difference was ascribed to the allelic substitution at a single gene locus; at 6 months of age it averaged 13-fold, immediately preceding the large divergence in leukemia incidence between the mutant and nonmutant mice.

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