References
Query Results -- Details
MGI Accession ID: MGI:1276231
J Number: J:48937
Other Accession IDs:
Title: A new murine model for mammalian wound repair and regeneration.
Authors: Clark LD; Clark RK; Heber-Katz E
Journal: Clin Immunol Immunopathol
Volume: 88
Issue: 1
Date: 1998 Jul
Year: 1998
Pages: 35-45
Review Status: Peer Reviewed
Abstract:
Regeneration is generally considered to be a phenomenon restricted to amphibians in which amputated limbs reform and regrow. We have recently noted a strain of mouse, the MRL, which displays a remarkable capacity for cartilagenous wound closure and provides an example of a phenomenon previously considered to be a form of regeneration. Specifically, through-and-through ear punches rapidly attain full closure with normal tissue architecture reminiscent of regeneration seen in amphibians as opposed to scarring, as usually seen in mammals. Histologically, we have demonstrated normal cell growth and microanatomy, including angiogenesis and chondrogenesis, as opposed to control C57BL/6 mice which have ear holes that contract minimally but do not close. Finally, this phenomenon is a genetically definable quantitative trait. Copyright 1998 Academic Press.
