References
Query Results -- Details
MGI Accession ID: MGI:1267155
J Number: J:48305
Other Accession IDs:
Title: Multigenic control of skin tumor susceptibility in SENCARA/Pt mice.
Authors: Mock BA; Lowry DT; Rehman I; Padlan C; Yuspa SH; Hennings H
Journal: Carcinogenesis
Volume: 19
Issue: 6
Date: 1998 Jun
Year: 1998
Pages: 1109-15
Review Status: Peer Reviewed
Abstract:
Skin tumors induced in mice by initiation-promotion (2 mu g DMBA-2 mu g TPA) protocols were found to be under multigenic control, Eighty-one N2 mice from the cross (BALB/cAnPt X SENCARA/Pt)F1 X SENCARA/Pt that were either solidly resistant (no papillomas) or highly susceptible (greater than or equal to 7 papillomas/mouse) were subjected to a 'genome scan' using 89 microsatellite markers to check for associations with susceptible and resistant phenotypes, A locus on Chr 5 (Skts4) was found to control the susceptibility of SENCARA/Pt mice and the resistance of BALB/cAnPt mice to papilloma formation. In addition, higher than expected linkage scores were seen for the markers D9Mit271, D11Mit268 and D12Mit56. Further work is required to establish whether genes determining papilloma formation are located in these regions of the genome, In general, no evidence was seen for loss of heterozygosity in microsatellite markers on Chrs 5, 9 and 11 in 17 microdissected papillomas from (BALB/c X SENCARA)F1 hybrid mice.
Additional Information:
