References
Query Results -- Details
MGI Accession ID: MGI:1203760
J Number: J:47547
Other Accession IDs:
Title: Molecular genetic dissection of mouse unconventional myosin-VA: tail region mutations. (Errata Genetics 1998 Nov;150:1331)
Authors: Huang JD; Mermall V; Strobel MC; Russell LB; Mooseker MS; Copeland NG; Jenkins NA
Journal: Genetics
Volume: 148
Issue: 4
Date: 1998 Apr
Year: 1998
Pages: 1963-72
Review Status: Peer Reviewed
Abstract:
We used an RT-PCR-based sequencing approach to identify the mutations responsible for 17 viable dilute alleles, a mouse-coat-color locus encoding unconventional myosin-VA. Ten of the mutations mapped to the MyoVA tail and are reported here. These mutations represent the first extensive collection of tail mutations reported for any unconventional mammalian myosin. They identify sequences important for tail function and identify domains potentially involved in cargo binding and/or proper folding of the MyoVA tail. Our results also provide support for the notion that different myosin tail isoforms produced by alternative splicing encode important cell-type-specific functions.
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