References
Query Results -- Details
MGI Accession ID: MGI:1101544
J Number: J:44966
Other Accession IDs:
Title: A major gene affecting age-related hearing loss in C57BL/6J mice
Authors: Johnson KR; Erway LC; Cook SA; Willott JF; Zheng QY
Journal: Hear Res
Volume: 114
Issue: 1-2
Date: 1997 Dec
Year: 1997
Pages: 83-92
Review Status: Peer Reviewed
Abstract:
A major gene responsible for age-related hearing loss (AHL) in C57BL/6J mice was mapped by analyses of a (C57BL/6J x CAST/Ei) x C57BL/6J backcross. AHL, as measured by elevated auditory-evoked brainstem response (ABR) thresholds, segregated among backcross mice as expected for a recessive, primarily single-gene trait. Both qualitative and quantitative linkage analyses gave the same genetic map position for the AHL gene (Ahl on chromosome 10, near D10Mit5. Marker assisted selection was then used to produce congenic lines of C57BL/6J that contain different CAST-derived segments of chromosome 10. ABR test results and cochlear histopathology of aged progenitors of these congenic lines are presented. Ahl is the first gene causing late-onset, non-syndromic hearing loss that has been reported in the mouse.
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