References
Query Results -- Details
MGI Accession ID: MGI:1097759
J Number: J:43458
Other Accession IDs:
Title: Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma [see comments]
Authors: Malmberg AB; Chen C; Tonegawa S; Basbaum AI
Journal: Science
Volume: 278
Issue: 5336
Date: 1997 Oct 10
Year: 1997
Pages: 279-83
Review Status: Peer Reviewed
Abstract:
In normal animals, peripheral nerve injury produces a persistent, neuropathic pain state in which pain is exaggerated and can be produced by nonpainful stimuli. Here, mice that lack protein kinase C gamma (PKCgamma) displayed normal responses to acute pain stimuli, but they almost completely failed to develop a neuropathic pain syndrome after partial sciatic nerve section, and the neurochemical changes that occurred in the spinal cord after nerve injury were blunted. Also, PKCgamma was shown to be restricted to a small subset of dorsal horn neurons, thus identifying a potential biochemical target for the prevention and therapy of persistent pain.
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