References
Query Results -- Details
MGI Accession ID: MGI:1097187
J Number: J:43130
Other Accession IDs:
Title: Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice.
Authors: Hautamaki RD; Kobayashi DK; Senior RM; Shapiro SD
Journal: Science
Volume: 277
Issue: 5334
Date: 1997 Sep 26
Year: 1997
Pages: 2002-4
Review Status: Peer Reviewed
Abstract:
To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase-deficient (MME-/-) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME-/- mice that received monthly intratracheal instillations of monocyte chemoattractant protein-1 showed accumulation of alveolar macrophages but did not develop air space enlargement. Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.
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