References
Query Results -- Details
MGI Accession ID: MGI:1095817
J Number: J:42494
Other Accession IDs:
Title: Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice.
Authors: Brion LP; Cammer W; Satlin LM; Suarez C; Zavilowitz BJ; Schuster VL
Journal: Am J Physiol
Volume: 273
Issue: 2 Pt 2
Date: 1997 Aug
Year: 1997
Pages: F234-45
Review Status: Peer Reviewed
Abstract:
Chronic metabolic acidosis (CMA) in the rabbit upregulates carbonic anhydrase (CA) IV in the proximal convoluted tubule (PCT). This study was designed to assess CA IV expression in a model of CMA in the mouse, i.e., congenital deficiency in CA II [CA(II)D]. In female CA(II)D mice, CA IV specific activity but not CA IV immunoreactivity was upregulated in the renal cortex, specifically in microdissected PCTs. Western blot analysis showed higher expression of CA IV immunoreactive protein in renal membranes from males than in those from females.
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