References
Query Results -- Details
MGI Accession ID: MGI:52461
J Number: J:3956
Other Accession IDs:
Title: Rescue of the tail defect of Brachyury mice.
Authors: Stott D; Kispert A; Herrmann BG
Journal: Genes Dev
Volume: 7
Issue: 2
Date: 1993 Feb
Year: 1993
Pages: 197-203
Review Status: Peer Reviewed
Abstract:
The mouse Brachyury (T) gene is required for normal development of axial structures. Embryos homozygous for the T mutation show severe deficiencies in mesoderm formation. They lack the notochord and allantois, have abnormal somites, and die at approximately 10 days postcoitum probably as a result of the allantois defect. Mice heterozygous for the T mutation exhibit a variable short-tailed phenotype. The T gene has been cloned and shown to be expressed in the tissues most strongly affected by the mutation. In this paper, we show that a single-copy transgene representing the wild-type T allele is able to rescue the T-associated tail phenotype. In addition, we show that increasing dosage of the T gene in Tc/+ mice causes an increased extension of the axis. These data show the correlation of the level of T product with the extension of the anteroposterior axis, directly demonstrating the involvement of the T product in this process.
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