References
Query Results -- Details
MGI Accession ID: MGI:84377
J Number: J:36967
Other Accession IDs:
Title: Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
Authors: Sornson MW; Wu W; Dasen JS; Flynn SE; Norman DJ; O'Connell SM; Gukovsky I; Carriere C; Ryan AK; Miller AP; Zuo L; Gleiberman AS; Andersen B; Beamer WG; Rosenfeld MG
Journal: Nature
Volume: 384
Issue: 6607
Date: 1996 Nov 28
Year: 1996
Pages: 327-33
Review Status: Peer Reviewed
Abstract:
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparent failure of initial determination of the Pit-1 lineage required for production of growth hormone, prolactin or thyroid-stimulating hormone, resulting in dysmorphogenesis and failure to activate Pit-1 gene expression. These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis.
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