References
Query Results -- Details
MGI Accession ID: MGI:83960
J Number: J:36532
Other Accession IDs:
Title: The dilute-lethal (dl) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice.
Authors: Takagishi Y; Oda S; Hayasaka S; Dekker-Ohno K; Shikata T; Inouye M; Yamamura H
Journal: Neurosci Lett
Volume: 215
Issue: 3
Date: 1996 Sep 13
Year: 1996
Pages: 169-72
Review Status: Peer Reviewed
Abstract:
The absence of smooth endoplasmic reticulum (SER) in the dendritic spine of Purkinje cells was found in dilute- lethal (d(l)) mouse cerebella as detected by immunohistochemistry using anti-inositol 1,4,5- triphosphate receptor antibody and electron microscopy. Since SER in the spine has been suggested to play a crucial role for synaptic regulation as an intracellular Ca2+ store (for reviews, see [Miller, R.J., Frog. Neurobiol., 37 (1991) 255-285; Simpson, P.B., Challiss, R.A.J. and Nahorski, S.R., Trends Neurosci., 18 (1995) 299- 306]), a neurological defect, characterized by clonic convulsions with opisthotonus and ataxia, in the dilute- lethal mouse with homozygous trait may be attributable to the absence of SER in the dendritic spine of Purkinje cells.
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