References
Query Results -- Details
MGI Accession ID: MGI:52076
J Number: J:3564
Other Accession IDs:
Title: Large deletions and other gross forms of chromosome imbalance compatible with viability and fertility in the mouse.
Authors: Cattanach BM; Burtenshaw MD; Rasberry C; Evans EP
Journal: Nat Genet
Volume: 3
Issue: 1
Date: 1993 Jan
Year: 1993
Pages: 56-61
Review Status: Peer Reviewed
Abstract:
Large deletions and other gross forms of chromosome imbalance are known in man but have rarely been found in the mouse. By screening progeny of spermatogonially irradiated male mice for a combination of runting and other phenotypic effects, we have identified animals that have large deletions comprising from 2.5-30 percent of the length of individual chromosomes, or other major chromosome changes, which are compatible with viability and fertility. Certain chromosome regions appear particularly susceptible to the generation of viable deletions and this has implications for radiation mutagenesis studies. Correlations with human deletions are also indicated.
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