References
Query Results -- Details
MGI Accession ID: MGI:82280
J Number: J:34814
Other Accession IDs:
Title: Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Authors: Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD
Journal: Cell Immunol
Volume: 171
Issue: 2
Date: 1996 Aug 1
Year: 1996
Pages: 186-99
Review Status: Peer Reviewed
Abstract:
The severe combined immunodeficiency (scid) mutation was backcrossed onto the C57BL/6J strain background in order to study the role of natural killer (NK) cells in rejection of normal and malignant human lymphohematopoietic cells. C57BL/6J-scid/scid mice showed severe loss of mature T and B cells accompanied by increased percentages of NK1.1+ cells and myeloid cells. Although little or no serum immunoglobulin was detectable prior to 2 months of age, all mice tested had circulating immunoglobulin by 7.5 months of age. C57BL/6J-scid/scid mice had markedly elevated levels of both hemolytic complement activity and NK cell activity
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