References
Query Results -- Details
MGI Accession ID: MGI:79132
J Number: J:31646
Other Accession IDs:
Title: TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor.
Authors: Steel KP; Davidson DR; Jackson IJ
Journal: Development
Volume: 115
Issue: 4
Date: 1992 Aug
Year: 1992
Pages: 1111-9
Review Status: Peer Reviewed
Abstract:
We have used a probe derived from TRP-2/DT to detect migratory melanoblasts shortly after they emerge from the neural crest, as early as 10 days post coitum (dpc). TRP-2/DT expression is otherwise restricted to the presumptive pigmented retinal epithelium, the developing telencephalon and the endolymphatic duct. The pattern of steel and c-kit hybridisation in the developing brain differed from that of TRP-2. TRP-1 and tyrosinase probes also detected melanoblasts but were both expressed later in development than TRP-2. We used the TRP-2/DT probe to investigate the way that the Steel-dickie (Sld) mutation interferes with melanocyte development, and found that the membrane-bound steel growth factor which is missing in Sld/Sld mutants is necessary for the survival of melanoblasts but not for their early migration and initial differentiation.
Additional Information:
