References
Query Results -- Details
MGI Accession ID: MGI:77803
J Number: J:30290
Other Accession IDs:
Title: The Ames dwarf gene is required for Pit-1 gene activation.
Authors: Andersen B; Pearse RV 2nd; Jenne K; Sornson M; Lin SC; Bartke A; Rosenfeld MG
Journal: Dev Biol
Volume: 172
Issue: 2
Date: 1995 Dec
Year: 1995
Pages: 495-503
Review Status: Peer Reviewed
Abstract:
The tissue-specific POU domain transcription factor Pit-1 is required for phenotypic specification of three cell types in the anterior pituitary gland of mammals: somatotropes, thyrotropes, and lactotropes. Mutations in the Pit-1 gene, as first described in Snell and Jackson dwarf (dw) mice, led to pituitary hypoplasia due to lack of these three cell types, as well as hypothyroidism and dwarfism because of deficiency of thyroid-stimulating hormone and growth hormone, respectively. The Ames dwarf (df) exhibits a phenotype identical to that of Pit-1- mutated mice but the defective gene has been mapped to a locus on mouse chromosome 11, distinct from the Pit-1 gene located on mouse chromosome 6. Our studies indicate that initial activation of the Pit-1 gene is deficient in the Ames dwarf. This suggests that the df gene is required for activation of the Pit-1 gene and provides evidence for a hierarchy of tissue-specific factors required for cellular commitment in the anterior pituitary gland. (C) 1995 Academic Press, Inc.
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