References
Query Results -- Details
MGI Accession ID: MGI:77341
J Number: J:29825
Other Accession IDs:
Title: Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein.
Authors: Henkemeyer M; Rossi DJ; Holmyard DP; Puri MC; Mbamalu G; Harpal K; Shih TS; Jacks T; Pawson T
Journal: Nature
Volume: 377
Issue: 6551
Date: 1995 Oct 26
Year: 1995
Pages: 695-701
Review Status: Peer Reviewed
Abstract:
The gene encoding p120-rasGAP, a negative regulator of Ras, has been disrupted in mice. This Gap mutation affects the ability of endothelial cells to organize into a highly vascularized network and results in extensive neuronal cell death. Mutati ons in the Gap and Nf1 genes have a synergistic effect, such that embryos homozygous for mutations in both genes show an exacerbated Gap phenotype. Thus rasGAP and neurofibromin act together to regulate Ras activity during embryonic development.
Additional Information:
