References
Query Results -- Details
MGI Accession ID: MGI:51412
J Number: J:2892
Other Accession IDs:
Title: Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.
Authors: Shull MM; Ormsby I; Kier AB; Pawlowski S; Diebold RJ; Yin M; Allen R; Sidman C; Proetzel G; Calvin D; Annunziata N; Doetschman T
Journal: Nature
Volume: 359
Issue: 6397
Date: 1992 Oct 22
Year: 1992
Pages: 693-9
Review Status: Peer Reviewed
Abstract:
Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.
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