References
Query Results -- Details
MGI Accession ID: MGI:51376
J Number: J:2856
Other Accession IDs:
Title: Wallerian degeneration in the optic nerve of the wabbler-lethal (wl/wl) mouse.
Authors: Carroll EW; Curtis RL; Sullivan DA; Melvin JL
Journal: Brain Res Bull
Volume: 29
Issue: 3-4
Date: 1992 Sep-Oct
Year: 1992
Pages: 411-8
Review Status: Peer Reviewed
Abstract:
Optic nerve pathology was studied in C57BL/6J wabbler-lethal (wl/wl) and control (+/+) mice at postnatal age of 4 weeks (P28). Qualitative light and ultrastructural pathology in wl/wl animals conformed to the criteria of primary axonal (Wallerian) degeneration. Most optic nerve axons in mutant animals appeared normal, as did oligodendroglia, the degree of myelination, the integrity and maturity of vascular elements, astroglia, and most myelin. Still, degenerating axons surrounded by somewhat normal myelin and axons with thickened myelin sheaths were prevalent in wl/wl mice. Dysmyelination or hypomyelination was not evident. At P28, pathology appeared more prominent in large diameter fibers. In the optic nerve of wl/wl mice, axonal degeneration preceded myelin disruption, adding this nerve to other previously reported systems undergoing Wallerian degeneration in this mutant.
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