References
Query Results -- Details
MGI Accession ID: MGI:51034
J Number: J:2511
Other Accession IDs:
Title: Effects of an Rb mutation in the mouse [see comments]
Authors: Jacks T; Fazeli A; Schmitt EM; Bronson RT; Goodell MA; Weinberg RA
Journal: Nature
Volume: 359
Issue: 6393
Date: 1992 Sep 24
Year: 1992
Pages: 295-300
Review Status: Peer Reviewed
Abstract:
The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.
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