References
Query Results -- Details
MGI Accession ID: MGI:69619
J Number: J:20512
Other Accession IDs:
Title: Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30;374(6521):479] [see comments]
Authors: Zhang Y; Proenca R; Maffei M; Barone M; Leopold L; Friedman JM
Journal: Nature
Volume: 372
Issue: 6505
Date: 1994 Dec 1
Year: 1994
Pages: 425-32
Review Status: Peer Reviewed
Abstract:
The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
Additional Information:
