References
Query Results -- Details
MGI Accession ID: MGI:50632
J Number: J:2108
Other Accession IDs:
Title: Genetic and molecular analysis of recessive alleles at the pink-eyed dilution (p) locus of the mouse.
Authors: Lyon MF; King TR; Gondo Y; Gardner JM; Nakatsu Y; Eicher EM; Brilliant MH
Journal: Proc Natl Acad Sci U S A
Volume: 89
Issue: 15
Date: 1992 Aug 1
Year: 1992
Pages: 6968-72
Review Status: Peer Reviewed
Abstract:
Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentation of both the coat and eyes. Here we describe the properties and complementation interactions of 10 p alleles, including 6 not previously reported. Several alleles that cause additional phenotypes affecting development, reproduction, and behavior were shown to be deletions by using DNA probes derived from the p region. An alignment of functional and marker-defined units is proposed, giving a linear complementation map that orders at least four functional loci. The characterization of a nested set of deletions around p will facilitate detailed molecular analyses of the genes and developmental functions associated with this part of the mouse genome.
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