References
Query Results -- Details
MGI Accession ID: MGI:67815
J Number: J:19675
Other Accession IDs:
Title: Genetic analysis of colon cancer susceptibility in mice.
Authors: Jacoby RF; Hohman C; Marshall DJ; Frick TJ; Schlack S; Broda M; Smutko J; Elliott RW
Journal: Genomics
Volume: 22
Issue: 2
Date: 1994 Jul 15
Year: 1994
Pages: 381-7
Review Status: Peer Reviewed
Abstract:
Mouse models may aid in the identification of genes involved in colon cancer. Our mating scheme involved mouse strains selected for maximum differences in susceptibility to DMH-induced colon tumors. Tumors were found in 40 of 122 progeny from a backcross to the resistant strain. We examined progeny animals for segregation of 177 genetic markers distributed at intervals of 5-30 cM on all mouse chromosomes. Multiple loci contribute to the phenotype, with significant linkage to a novel locus, Ccs1, between D12Mit5 and D12Mit6 on mouse Chr 12. Comparative maps suggest that the human homologue of Ccs1 is near FOS on human chromosome 14q.
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