References
Query Results -- Details
MGI Accession ID: MGI:65465
J Number: J:17427
Other Accession IDs:
Title: Physiological consequences of loss of plasminogen activator gene function in mice.
Authors: Carmeliet P; Schoonjans L; Kieckens L; Ream B; Degen J; Bronson R; De Vos R; van den Oord JJ; Collen D; Mulligan RC
Journal: Nature
Volume: 368
Issue: 6470
Date: 1994 Mar 31
Year: 1994
Pages: 419-24
Review Status: Peer Reviewed
Abstract:
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.
Additional Information:
