References
Query Results -- Details
MGI Accession ID: MGI:64473
J Number: J:16392
Other Accession IDs:
Title: Modified hippocampal long-term potentiation in PKC gamma-mutant mice.
Authors: Abeliovich A; Chen C; Goda Y; Silva AJ; Stevens CF; Tonegawa S
Journal: Cell
Volume: 75
Issue: 7
Date: 1993 Dec 31
Year: 1993
Pages: 1253-62
Review Status: Peer Reviewed
Abstract:
Calcium-phospholipid-dependent protein kinase (PKC) has long been suggested to play an important role in modulating synaptic efficacy. We have created a strain of mice that lacks the gamma subtype of PKC to evaluate the significance of this brain-specific PKC isozyme in synaptic plasticity. Mutant mice are viable, develop normally, and have synaptic transmission that is indistinguishable from wild-type mice. Long-term potentiation (LTP), however, is greatly diminished in mutant animals, while two other forms of synaptic plasticity, long-term depression and paired-pulse facilitation, are normal. Surprisingly, when tetanus to evoke LTP was preceded by a low frequency stimulation, mutant animals displayed apparently normal LTP. We propose that PKC gamma is not part of the molecular machinery that produces LTP but is a key regulatory component.
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