References
Query Results -- Details
MGI Accession ID: MGI:50074
J Number: J:1547
Other Accession IDs:
Title: Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1.
Authors: von Deimling OH; Groning J; Gaa A
Journal: Biochem Genet
Volume: 29
Issue: 11-12
Date: 1991 Dec
Year: 1991
Pages: 545-57
Review Status: Peer Reviewed
Abstract:
Genetic variation of a codominantly inherited pancreas protease, designated CTRA-1, was discovered in the house mouse by isoelectric focusing in polyacrylamide gels. Phenotype CTRA-1A was found in MOLH/Fre and in the majority of common laboratory mouse strains. Phenotype CTRA-1B was found in PWD/Ph. It was characterized by the absence of a corresponding protease band. A third phenotype, CTRA-1C, was observed in IS/Cam and a fourth phenotype, CTRA-1D, was detected in SEG/1. CTRA-1 was found only in the pancreas and may represent the A form of chymotrypsin. The enzyme was shown to be controlled by the presumed structural locus Ctra-1 located on chromosome 8. From two backcross series, including a total of 274 animals, the gene order (Es-1, Es-9)-3.9 +/- 1.7%-Got-2-3.9 +/- 1.7%-(Es-2, Es-7, Es-23)-0.7 +/- 0.5%- Ctra-1-6.3 +/- 2.2%-Prt-2 was established.
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