References
Query Results -- Details
MGI Accession ID: MGI:4355245
J Number: J:151758
Other Accession IDs:
Title: Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
Authors: Ilarregui JM; Croci DO; Bianco GA; Toscano MA; Salatino M; Vermeulen ME; Geffner JR; Rabinovich GA
Journal: Nat Immunol
Volume: 10
Issue: 9
Date: 2009 Sep
Year: 2009
Pages: 981-91
Review Status: Peer Reviewed
Abstract:
Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-dependent regulatory function, promoted IL-10-mediated T cell tolerance and suppressed autoimmune neuroinflammation. Consistent with its regulatory function, galectin-1 had its highest expression on DCs exposed to tolerogenic stimuli and was most abundant from the peak through the resolution of autoimmune pathology. DCs lacking galectin-1 had greater immunogenic potential and an impaired ability to halt inflammatory disease. Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology.
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