References
Query Results -- Details
MGI Accession ID: MGI:4352797
J Number: J:151115
Other Accession IDs:
Title: Amygdala protein kinase C epsilon controls alcohol consumption.
Authors: Lesscher HM; Wallace MJ; Zeng L; Wang V; Deitchman JK; McMahon T; Messing RO; Newton PM
Journal: Genes Brain Behav
Volume: 8
Issue: 5
Date: 2009 Jul
Year: 2009
Pages: 493-9
Review Status: Peer Reviewed
Abstract:
Alcoholism is a progressive disorder that involves the amygdala. Mice lacking protein kinase C epsilon (PKCepsilon) show reduced ethanol consumption, sensitivity and reward. We therefore investigated whether PKCepsilon signaling in the amygdala is involved in ethanol consumption. Local knockdown of PKCepsilon in the amygdala reduced ethanol consumption and preference in a limited-access paradigm. Further, mice that are heterozygous for the PKCepsilon allele consume less ethanol compared with wild-type mice in this paradigm. These mice have a >50% reduction in the abundance of PKCepsilon in the amygdala compared with wild-type mice. We conclude that amygdala PKCepsilon is important for ethanol consumption in mice.
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