References
Query Results -- Details
MGI Accession ID: MGI:3852607
J Number: J:150977
Other Accession IDs:
Title: Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia.
Authors: Karnik P; Tekeste Z; McCormick TS; Gilliam AC; Price VH; Cooper KD; Mirmirani P
Journal: J Invest Dermatol
Volume: 129
Issue: 5
Date: 2009 May
Year: 2009
Pages: 1243-57
Review Status: Peer Reviewed
Abstract:
Primary cicatricial or scarring alopecias (CA) are a group of inflammatory hair disorders of unknown pathogenesis characterized by the permanent destruction of the hair follicle. The current treatment options are ineffective in controlling disease progression largely because the molecular basis for CA is not understood. Microarray analysis of the lymphocytic CA, Lichen planopilaris (LPP), compared to normal scalp biopsies identified decreased expression of genes required for lipid metabolism and peroxisome biogenesis. Immunohistochemical analysis showed progressive loss of peroxisomes, proinflammatory lipid accumulation, and infiltration of inflammatory cells followed by destruction of the pilosebaceous unit. The expression of peroxisome proliferator-activated receptor (PPAR) gamma, a transcription factor that regulates these processes, is significantly decreased in LPP. Specific agonists of PPARgamma are effective in inducing peroxisomal and lipid metabolic gene expression in human keratinocytes. Finally, targeted deletion of PPARgamma in follicular stem cells in mice causes a skin and hair phenotype that emulates scarring alopecia. These studies suggest that PPARgamma is crucial for healthy pilosebaceous units and it is the loss of this function that triggers the pathogenesis of LPP. We propose that PPARgamma-targeted therapy may represent a new strategy in the treatment of these disorders.
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