References
Query Results -- Details
MGI Accession ID: MGI:3848385
J Number: J:149374
Other Accession IDs:
Title: Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.
Authors: Loane DJ; Pocivavsek A; Moussa CE; Thompson R; Matsuoka Y; Faden AI; Rebeck GW; Burns MP
Journal: Nat Med
Volume: 15
Issue: 4
Date: 2009 Apr
Year: 2009
Pages: 377-9
Review Status: Peer Reviewed
Abstract:
Amyloid-beta (Abeta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of Abeta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss after experimental TBI in mice. Thus, APP secretases are promising targets for treatment of TBI.
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